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Abstract: This work presents the exergy execution of new innocuous to the biological system refrigerants 1,1-difluoroethane (R152a) ,1,1,1,3,3-Pentafluorbutane (R365mfc) and particularly their mix. A smoke pressure refrigeration cycle was reenacted to see the introduction of a lone stage cycle at different conditions. A close to report including a broad assortment of effective parameters was done. The exergy annihilation methodology as one more part for the arrangement of the smoke pressure refrigeration cycles was completed. R365mfc has achieved higher Coefficient of Execution (COP). Other than an exergy examination was employed for each part and for the whole cycle. Among all of, the mixes of R152a and R365mfc have given higher exergy destruction, power consumption, cooling and heating capacity as compared with the pure fluids.