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Abstract: The Research paper studies the Development of cross platform applications using two most popular library and framework, Node.js and React Native. Node.js is a JavaScript runtime built on Chrome's V8 JavaScript engine. It allows you to run JavaScript on the server side, creating web servers and other server-side applications with JavaScript. React Native is a JavaScript framework for building native mobile applications. It was developed by Face book and allows developers to create mobile applications for iOS and Android using JavaScript and the React library. Some specifications which are explained inside the paper and it also help us to know reason to choose React Native with Node.js and how we can setup both the frameworks in our system and create a project using both the frameworks with database connectivity. Basically, this paper covers everything required for a person or a student to get started with the development of cross platform applications with this wonderful integration and learn the basics to create some beginner to advance level projects related to the MERN stack development and make learning interactive and easy for everyone. Key Word: React Native; Node JS; References [1]. "Learning React Native: Building Native Mobile Apps with JavaScript 2nd Edition” by Bonnie Eisenman. [2]. "React Native in Action - Developing iOS and Android apps with JavaScript " by Nader Dabit. [3]. The official React Native documentation (https://reactnative.dev/). [4]. “Node.js in Action 2nd Edition” by Alex R. Young, Bradley Meck, Mike Cantelon, Tim Oxley, Marc Hater, TJ Holowaychuk, and Nathan Rajlich. [5]. “Node.js the Right Way: Practical, Server-Side JavaScript That Scales 1st Edition” by Jim R. Wilson. [6]. “The Road to React: Your journey to master React.js in JavaScript” by Robin Wieruch. [7]. The Node.js tutorials on the MDN Web Docs (https://developer.mozilla.org/en-US/docs/Learn/Server-side/Express_Nodejs). [8]. “React in Action” by Mark Tielens Thomas. [9]. “MongoDB: The Definitive Guide” by Kristina Chodorow and Michael Dirolf. [10]. “Practical MongoDB: Architecting, Developing, and Administering MongoDB First Edition” by Shakuntala Gupta Edward and Navin Sabharwal. [11]. The MongoDB University (https://university.mongodb.com/).