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Abstract: Inflammation is a reaction of the immune system to the removal of foreign stimuli from the body. A clinical need exists for noninvasive tools capable of tracking inflammation levels continuously for patients with inflammatory diseases. This review aims to demonstrate devices and methods that can be utilized to test and quantify inflammation noninvasively in vivo. The methods are categorized based on five main cardinal signs related to inflammation; pain, swelling, redness, heat, and loss of function related to inflammation. The paper also explores possible techniques to detect and monitor related physiological changes such as inflammatory biomarkers, and oxygen deficiency.