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Abstract: This work presents the drenching pressure of new innocuous to the biological system refrigerants 1,1-difluoroethane (R152a)and1,1,1,3,3-Penta fluor butane (R365mfc), beside their mixture. Special attention was given toenablea highly accurate predicted submersion strain and excess Gibbs energy data as capacity of design in a temperature extent of T=260K toT=380K, for the pure fluid and the mixture.The multiplication data for the inundation pressure were gotten using the modifiedUnifac technique, Lee Kesler and Hoffman Florin models and supported with the high exactness essential states of state by Outcaltand McLindenfrom National Institute of Standardand Technology (NIST). Among all the model of Lee and Keslerhave shown extraordinary results for fitting the light aspect R152a, most outrageous positive deviation under 1% was reached. Where asthe model of Hoffman Florin yielded extraordinary results for R365mfc, most outrageous positive deviation under 2.85% was reached. The excess Gibbs energy capacity for the blend was recognized in a temperature extent of T=260K to T=380K by the modified UNIFAC method.